Integrative research on the mechanisms of acupuncture mechanics
and interdisciplinary innovation (2025 China)
This paper delves into the entire mechanical process of acupuncture, from skin penetration to point stimulation, and analyzes tissue responses to provide a solid theoretical foundation for the scientific study of acupuncture.
The Mechanism of Acupuncture Regulating Autophagy:
Progress and Prospect (2025 China)
https:/pubmed.ncbi.nlm.nih.gov/40001566//
Apoptosis and autophagy are two important cellular processes
which control cell survival or death,
and also considered as a balanced response to pathogens and
other immune stimuli that play an important role in maintaining physiologic homeostasis.
There are few effective and safe ways to regulate cell apoptosis and autophagy
in clinical practice right now.
Modulation of acupuncture on cell apoptosis and autophagy (2017, China)
Regulating autophagy is one of the mechanisms
through which acupuncture exerts its therapeutic effects.
The regulatory effect of acupuncture on autophagy capacity is bidirectional:
it inhibits the abnormal activation of autophagy to prevent exacerbation of injury
and reduce apoptosis, while also activating or enhancing autophagy
to promote the elimination of inflammation and reduce oxidative stress.
Autophagy is a complex molecular pathway by which eukaryotic cells
degrade longlived proteins, organelles, and pathogens,
and recycle some of the energy required for recirculation to maintain
cellular and organismal homeostasis.
Autophagy is involved in intercellular communication;
responding to cellular stress; senescence, and death;
inhibiting inflammatory responses; and improving organismal metabolism.
Acupuncture promotes self-regulation through an autostable mechanism,
with its direction of action contingent on the body’s pathological conditions.
Whether addressing abnormal autophagy resulting from various diseases
(either overactivation or under-activation) or
autophagy disorders that manifest at different stages of the same disease,
acupuncture can help restore the body’s functions from a biased state to a balanced one.
This underscores the bidirectional regulatory effect of acupuncture.
This paper systematically reviews the research progress on the use of acupuncture
for treating various diseases via the autophagy pathway.
