Caffeine Impaired Acupuncture Analgesia in Inflammatory Pain
by Blocking Adenosine A1 Receptor
(2024 USA)
https://pubmed.ncbi.nlm.nih.gov/37918469/
https://www.jpain.org/article/S1526-5900(23)00598-9/fulltext
J Pain. 2024 Apr;25(4):1024-1038.
Our study suggested that caffeine consumption should be avoided during acupuncture treatment. This highlights the importance of monitoring caffeine intake during acupuncture treatment.
Needles and Coffee May Not Mix;
Even a Low Dose of Caffeine Blocks
Acupuncture’s Pain Relief in Mice
(2017 USA)
https://www.nccih.nih.gov/research/research-results/needles-and-coffee-may-not-mix-even-a-low-dose-of-caffeine-blocks-acupunctures-pain-relief-in-mice
Recent research in mice suggests that ingesting even a low dose of caffeine may interfere
with the analgesic effects of acupuncture in acute and chronic pain models.
Previous animal research showed that the analgesic effect of acupuncture is mediated
by a steep increase in extracellular adenosine levels at the acupuncture point
and subsequent local activation of the adenosine A1 receptor.
Furthermore, adenosine receptor activation during acupuncture
is potentially impacted by caffeine, which is a potent adenosine receptor antagonist.
Since a detectable amount of caffeine stays in the body for more than 12 hours
after drinking one cup of coffee, a residual amount of caffeine could be present
at the time of acupuncture treatment in people who ingest caffeine daily.
The researchers used male and female mice that were 8–12 weeks old.
In some experiments, animals were given drinking water supplemented with caffeine
while other mice were given water without caffeine.
The scientists induced acute inflammatory pain via injection
directly into the animals’ left hind-limb ankle joints;
they induced chronic inflammatory pain via injection into the left hind-limb knee joints.
In other experiments,
mice were injected with caffeine or saline at a specific acupuncture point.
Mice also received sham acupuncture treatment,
in which a needle was inserted into the same acupuncture point but not rotated
(as it was during active treatment).
For the acute pain model,
mice that did not ingest caffeine showed a 35 percent reduction
in sensitivity following acupuncture treatment;
mice that drank caffeine-laced water showed no such reduction with acupuncture.
In the chronic pain model,
a low dose of caffeine—0.1 mg/mL—blocked the analgesic effects of acupuncture,
and at higher doses (0.2 and 0.3 mg/mL), acupuncture appeared to worsen the pain.
A follow-up series of experiments suggested that the pain-relieving effects
of acupuncture were restored after eliminating caffeine exposure.
The scientists speculate that even a small amount of caffeine in the body,
even hours after consuming one cup of coffee,
could potentially reduce the efficacy of acupuncture.
They suggest that, for some people, eliminating regular consumption of caffeine
may enhance the efficacy of acupuncture for pain relief.
However, clinical studies are needed to confirm this, and to see
how long people would need to stop ingesting caffeine to improve acupuncture’s effects.
Reference
Fujita T, Feng C, Takano T. Presence of caffeine reversibly interferes with efficacy of acupuncture-induced analgesia. Scientific Reports. 2017;7:3397.
Presence of caffeine reversibly interferes with efficacy of
acupuncture-induced analgesia
(2017 USA)
https://pubmed.ncbi.nlm.nih.gov/28611421
Acupuncture induces analgesia through local activation of the adenosine A1 receptor,
caffeine blocks receptor activation and inhibits acupuncture analgesia even at a low dose.
Caffeine withdrawal restored acupuncture’s anti-nociceptive effect.
Even though the average half-life of caffeine in plasma is 4–5 hours, a detectable amount of caffeine stays in the body for more than 12 hours after drinking a cup of coffee.
Therefore, it is likely that a residual amount of caffeine could be present at the time of acupuncture treatment in those who ingest caffeine daily.
A trace amount of caffeine can reversibly block the analgesic effects of acupuncture,
and controlling caffeine consumption during acupuncture may improve pain management outcomes.
Caffeine withdrawal fully restored the efficacy of acupuncture by the next day, and long-term exposure to caffeine did not alter A1 receptor expression at the acupuncture point.
Results
– Caffeine interferes with the analgesic effect of acupuncture in acute inflammatory pain.
– Caffeine interferes with the analgesic effect of acupuncture in chronic pain in a dose dependent manner.
– The presence of caffeine at the acupuncture site abolishes the analgesic effect of
acupuncture.
– Caffeine habituation does not alter the mechanism of acupuncture-induced analgesia.
Caffeine is known to induce mild physical dependency associated with sustained physiological and molecular changes after daily consumption.
– Full restoration of the analgesic effect of acupuncture was observed in both groups after caffeine withdrawal.
After 24 hours, there were no detectable levels of caffeine present in the plasma in 0.3 mg/ml and 0.6 mg/ml caffeine groups compared to No caffeine group.
Discussion
We adapted both acute ankle joint and chronic knee joint inflammatory pain models and successfully demonstrated that manual acupuncture treatment induced acute analgesia.
Caffeine consumption, ranging from low to high amounts (equivalent to 1–10 cups of coffee
a day in humans), interfered with the analgesic action of acupuncture.
A small volume of caffeine administered at the acupuncture point, without raising systemic caffeine concentration, also completely blocked the effect of acupuncture, indicating that caffeine at the acupuncture point without systemic presence is sufficient to abolish the analgesic effect of acupuncture.
Kofeiin võib pärssida nõelravi analgeetilist toimet,
näitasid Brasiilias läbiviidud loomkatsed. (2013)
Hiirtel teostati plantaarintsisioon (lõige käpa tallale), mille järgselt said nad manuaalset ja elektroakupunktuuri akupunktile Sanyinjiao Sp 6. Enne nõelravi läbiviimist manustati neile akuutne või krooniline doos kofeiini.
Selgus, et nõelravi eelselt akuutne kofeiini manustamine annulleeris täielikult nõelravi valuvaigistava toime mõlemas nõelravigrupis. Võrreldi ka Euroopas ja Hiinas tavapäraselt kasutatava kofeiini annust imiteeriva doosi mõju. Kaheksa ööpäeva vältel lisati hiirte joogivette kofeiini.
“Lääne riikides” kasutatava kofeiini doosi (70mg/kg/ööpäevas) foonil nõelravi valuvaigistav toime ei avaldunud, kuid Hiinas keskmiselt kasutatava annuse puhul (4mg/kg/ ööpäevas) avaldus.
Autorite arvates tuleks inimestel läbiviidud nõelraviuuringute puhul arvestada tarbitud kofeiini mõju.
Caffeine at Moderate Doses Can Inhibit Acupuncture-Induced Analgesia in a Mouse Model of Postoperative Pain. J Caffeine Res. 2013 Sept;3(3):143-148.
Liigsed tassitäied kohvi päevas võivad kaasa tuua ohtliku haiguse
tervis.postimees.ee
3. juuli 2022
Paljud naudivad kohvi terve päeva vältel, tassitäite viisi, kuid uue uuringu kohaselt võib liiga palju kohvi ajumahtu vähendada ja pikemas perspektiivis suurendada dementsuse riski, vahendab Science Alert.
Uuringus osales 17 702 inimest vanuses 37–73, kelle andmed võeti Ühendkuningriigi biopanga projektist. Selle raames kogutakse teavet paljude erinevate tervise- ja elustiili mõõdikute kohta, sealhulgas kohvi tarbimine, ajumaht ja haigused, lisaks näiteks sotsiaalmajanduslik olukord, mida teadlased saavad arvesse võtta.
Uuring näitas, et päevas kuus või enam tassitäit kohvi joovatel inimestel oli dementsuse tõenäosus 53 protsenti suurem kui neil, kes jõid ühe või kaks tassi või vähem.
«Kohv on üks populaarsemaid jooke maailmas,» ütleb epidemioloog Kitty Pham Lõuna-Austraalia ülikoolist. «Kuid kui ülemaailmne tarbimine ületab üheksa miljardit kilogrammi aastas, on oluline mõista kõiki võimalikke tervisemõjusid.»
«See on kõige ulatuslikum uuring kohvi, ajumahu, dementsuse ja insuldiriskide vaheliste seoste kohta – see on suurim uuring, milles võeti arvesse ajumahu piltide andmeid ja mitmesuguseid muid tegureid.»
Kuigi teame, et kohv mõjutab aju mitmel viisil — sealhulgas hoiab meid erksana —,
on varasemad uuringud olnud ajumahu ja dementsuse vaheliste seoste osas ebaselged
ja mõnel juhul vastuolulised.
Pärast selliste muutujate arvesse võtmist, nagu sugu, vanus, kehamassiindeks ja pikaajalised haigused, leidsid teadlased seose suurema kohvitarbimise ja väiksema aju kogumahu ning dementsuse suurenenud riski vahel.
«Arvestades kõiki võimalikke tegureid, leidsime järjepanu, et suurem kohvitarbimine oli oluliselt seotud aju vähenenud mahuga – sisuliselt võib üle kuue tassi kohvi joomine päevas kaasa tuua ajuhaigusi, nagu dementsus ja insult,» ütleb Pham.
Mis pole selge, on põhjus, miks see juhtub: on vaja veel palju uurida,
kuidas kofeiin suhtleb ajurakkudega, olgu need kontaktid lõpuks positiivsed või negatiivsed.
On võimalik, et viis, kuidas kofeiin seondub aju adenosiini retseptoritega,
on üks mõjur muutuste taga, ehkki neid võib kaasa tuua hoopis mõju teistele kehaosadele – näiteks südame-veresoonkonnale.
Uuring ilmus ajakirjas Nutritional Neuroscience.
